Infantile Leukocoria: the white pupil

Charlotte Buscombe, Sophie Headland

Abstract

Leukocoria (a white pupil) in a child can signify serious intraocular disease. This educational review uses an anatomical framework to review the most common causes of infantile leukocoria, considering the anterior chamber/lens, vitreous, retina and optic nerve in turn. Through adopting such a systematic approach, it is hoped clinicians faced with this unfamiliar clinical sign will be better enabled to formulate possible differentials, and to correctly judge the urgency of referral to ophthalmology required.

Keywords: leukocoria, retinoblastoma, cataract